The first step of AAV infection often requires the attachment of the capsid to carbohydrate moieties on the cell surface. Of the 11 well-characterized AAV serotypes, heparan sulfate proteoglycan and sialic acid have been suggested to be the attachment receptors for AAV type 2 and types 4 and 5, respectively. In this report, we identify the receptor for the two closely related serotypes, AAV1 and AAV6. If you loved this post and you want to receive more information with regards to manufacturer of sialic acid powder as Raw Material for beverages please visit the site. First, we demonstrate using coinfection experiments and luciferase reporter analysis that AAV1 and AAV6 compete for similar receptors.
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