1 To acquire hemoglobin, a pressure of E. coli bacteria that has the ability to provide human hemoglobin is used. Synthetic hemoglobin-primarily based products are produced from hemoglobin harvested from an E. coli bacteria pressure. There are 20 naturally occurring organic amino acids manufacturer acids which may be used to supply hemoglobin. There are two significantly completely different products that are below development as blood substitutes. There are additionally issues with the stability of hemoglobin in a solution. Unlike PFC products the place dissolving is the key mechanism, oxygen covalently bonds to hemoglobin.