Finally, is there a threshold of sialic acid loss that must be attained before barrier disruption occurs? More specifically, treatment of endothelial monolayers with neuraminidases leads to endothelial barrier disruption. In the event you loved this post and you would want to receive much more information about Supplier of sialic acid powder for pharmaceutical Ingredients generously visit the web-site. However, the fact that there was an actual increase in resistance suggests that there is something more going on, something we do not yet understand.