The conformational ensemble of the complex is modulated via publish-translational modifications or protein interactions. Often, publish-translational modifications resembling phosphorylation tune the affinity (not not often by a number of orders of magnitude) of individual linear motifs for specific interactions. Many disordered proteins have the binding affinity with their receptors regulated by submit-translational modification, thus it has been proposed that the flexibility of disordered proteins facilitates the completely different conformational requirements for binding the modifying enzymes as well as their receptors. Figure 2. If you liked this short article and you would like to receive extra details relating to https://www.accobio.com kindly check out our web-site. 35 Conformational flexibility in SUMO-1 protein (PDB:1a5r).
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