Which application/end-user or product type may seek incremental growth prospects? AAV6 binding appears to be less affected by neuraminidase compared with AAV1 binding, suggesting that AAV6 may also bind to moieties other than sialic acid on the cell surface. These data suggest that sialic acid present on the cell surface is required for efficient AAV1 and AAV6 transduction. Taken together, these results show that both enzymatic removal and genetic removal of sialic acid on the cell surface reduce AAV1 and AAV6 binding and transduction. If you beloved this article therefore you would like to acquire more info with regards to Supplier of sialic acid powder as Raw Material for pharmaceuticals generously visit our page. WGA, which binds to all linkage forms of sialic acid, blocked both AAV1 and AAV6 transduction on all the cells tested.
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