Cannabinoids, the active compounds in cannabis, have been extensively studied for their potential in managing chronic pain. Recent research provides insights into their efficacy and safety: Comparative Effectiveness with Opioids A systematic review and network meta-analysis evaluated the benefits and harms of medical r&d cannabis versus opioids for chronic non-cancer pain. The study found that both cannabinoids and opioids offer small improvements in pain relief, physical functioning, and sleep quality compared to placebo.
Notably, cannabis resulted in fewer discontinuations due to adverse events than opioids, suggesting a more favorable safety profile. BMJ OPEN Clinical Practice Guidelines The BMJ issued a clinical practice guideline recommending a trial of non-inhaled medical cannabis or cannabinoids for individuals with chronic pain unresponsive to standard care.
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