Finally, is there a threshold of sialic acid loss that must be attained before barrier disruption occurs? More specifically, treatment of endothelial monolayers with neuraminidases leads to endothelial barrier disruption. If you have any issues with regards to where by and how to use manufacturer of sialic acid powder as Raw Material for Supplements, you can speak to us at our internet site. However, the fact that there was an actual increase in resistance suggests that there is something more going on, something we do not yet understand.