translational-medicine.com/content/9/1/Page 11 ofIL-6 and IL-1b production by
Www.translational-medicine.com/content/9/1/Page 11 ofIL-6 and IL-1b production by human monocytes [15,16]. In addition, hAAT completely suppressed macrophage inflammatory protein-2 (MIP-2)/monocyte chemotactic protein-1 (MCP-1) gene expression in lung [39]. Human AAT also enhanced anti-inflammatory cytokine IL-10 production from monocytes [15]. As a consequence of interfering with the cytokine/chemokine network, hAAT may also inhibit polymorphonuclear leukocyte (PMN) invasion into the joint. Churg et al. demonstrated that hAAT inhibited silica-induced PMN influx into the lung and partially suppressed nuclear transcription factor B (NF-B) translocation and increased inhibitor of NF-B (I-B) levels in a mouse model of acute PMN mediated inflammation [39]. Thus, it is possible
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