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These results give proof that ET-1 drives smooth muscle contraction in the penis by increasing intracellular Ca2+ levels and Peptide Hormonal Modulation increasing Ca2+ level of sensitivity click through the up coming post PKC activation (Fig. 7). DAG, the other item of PLC, triggers protein kinase C (PKC) which can additionally drive smooth contraction [Hilgers and Webb, 2005] PKC phosphorylates the CPI-17 healthy protein, Peptide Sexual Health Products which consequently prevents MLCP (drives smooth muscular tissue leisure) and thus boosts Ca2+ sensitization (Fig. 7) [Li et al., 1998; Nunes et al.